[Time Sequential OTC Drug Actions]

Envision a 3-hour TRAIN, where patients board the train at time zero, and the first stop is at 2.5 hours after embarking and and the last stop is 3-5 hours to disembark. 

• Time 0- Ingestion of necessary dietary Proteins and Amino Acids with each meal. Dietary protein restriction causes growth retardation and is to be avoided.
• Time 0- Ingest leafy green salad or cereal (Bran Buds)(Shredded Wheat) or comparable dietary means  
• Time 0- Ingestion of CHELATEXX two 320 mg enteric coated capsules (or three capsules determined from the NIH/NIA funded Clinical Study by PPD   PPD.com) with each meal
• Time 0- Ingestion of CHELATEXX VIT-C 250 mg capsule with each meal
• Time 0 + 30 minutes CHELATEXX VIT-C dissolves in the stomach and transits the small intestines
• Time 0+2.5 hours after ingestion, CHELATEXX VIT-C (ascorbic acid) is absorbed by active facilitated diffusion in the last, distal 10 cm of the small bowel (intestines) to prevent Vit C deficiency
• Time 0+3 hours after ingestion, CHELATEXX VIT-C excess VIT-C (ascorbic acid) is advanced to the proximal colon to acidify the colon to pH of 5 to prevent neurotoxic ammonia systemic absorption from the colon,( for 3-5 hours). Castell and Moore reference.
• Time 0+3 hours after ingestion, enteric coating of the USP 1600 AC dissolves releasing the USP 1600 AC into the proximal colon (large intestines) to absorb about 50% (proprietary Beagle Dog Study proof) of the neurotoxic ammonia for 3 to 5 hours after ingestion  (this reduces the neurotoxic ammonia from 68.8 micrograms/dl (Fisman reference) to below 40 micrograms/dl.

Castell and Moore reference  "Ammonia absorption from the human colon"  gastrojournal.org/articla/S0016-5085(71)80004-5/pdf

FIG #5 Percentage of colonic absorption of ammonia for each of 4 subjects

#1     20% at pH 5     40% at pH 9
#2     20% at pH 5     40% at pH 9
#3     30% at pH 5     50% at pH 9
# 4    50% at pH 5     70%at pH 9

Proprietary and Private Beagle Dog Study reference

Oral AST-120 Activated Charcoal decreased serum ammonia by 39% in one Beagle Dog

Oral AST-120 Activated Charcoal decreased serum ammonia by 49% in the second Beagle Dog

Fisman reference "Hyperammonemia in Alzheimer's disease"  www.pubmed.gov/3966587

Alzheimer's disease patients             68.8 micrograms/dl of blood ammonia
Hospital control patients                    44.8 micrograms/dl of blood ammonia
Community control patients               46.2 micrograms/dl of blood ammonia