First Action to Prevent Ammonia Production, Hyperammonemia, and Progressive Cognitive Decline
About Chelatexx
The U.S. National Institutes of Health/National Institute on Aging (NIH/NIA) have invited CHELATEXX developers to apply for cognitive decline/Alzheimer's disease clinical trials research funding. This is a direct result of CHELATEXX's ability to absorb neurotoxic ammonia, from dysbiosis, abnormal colonic microbiome. This was proven in our preclinical Beagle Dog Study of hyperammonemia prevention with oral activated charcoal, reducing serum ammonia by 39% and 49%.
"Changes in Human Microbiome Precede Alzheimers Cognitive Declines"
Ammonia Facts
- Ammonia is a potent neurotoxin even in very small amounts and causes permanent brain damage. (neuroassualts.com).
- Ammonia NH3 is a gas and easily traverses the brain-protecting blood-brain-barrier to assault the brain.
- Ammonia is normally produced daily in the colonic microbiome by the normal digestion of dietary amino acids and proteins.
- Ammonia is normally absorbed by the hepatic portal system and detoxified by the liver urea cycle enzymes.
- Elevated serum ammonia levels are known as hyperammonemia.
About HYPERAMMONEMIA
(NIH April 2023) Drs Rimsha Ali and Shivaraj Nagalli
- Hyperammonemia is a metabolic condition, and like diabetes and hypertension, hyperammonemia is silent.
- Hyperammonemia most commonly presents with neurological signs and symptoms. Acute as in Urea Cycle Disorders, or Chronic as in Cognition Impairment or Dementia.
- Hyperammonemia mainly presents with neurological signs and symptoms due to its neurotoxic effects. (Neurotoxic effects are cumulative with time)
- Ammonia is a potent neurotoxin.
- The exact mechanism by which ammonia results in CNS (Central Nervous System=BRAIN) damage has not been established.
Hyperammonemia in Alzheimer's Disease
In 1985, Dr Fisman et al reported "Postprandial blood ammonia levels were significantly higher in 22 patients with Alzheimer's disease than 37 control subjects"
Normal blood levels in adults below 50 micrograms/dl. Hyperammonemia above 50 micrograms/dl.
Alzheimer's disease patients.........68.8 micrograms/dl of blood ammonia
Hospital control patients.............44.8 micrograms/dl of blood ammonia
Community control patients.........46.2 micrograms/dl of blood ammonia